GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11976180 | 1 | rs1320894 | chr7:143751802 | OR2A7 | chr7:143955790-143974852:- | 0.19 | 4.58 | 5.22E-6 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs1320894 | chr7:143751802 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.13 | -3.41 | 0.000681 | Obesity-related traits |
| BRCA | cis | rs13191362 | 1 | rs13209728 | chr6:162997533 | PACRG | chr6:163148164-163736523:+ | 0.22 | 4.35 | 1.52E-5 | Body mass index |
| BRCA | cis | rs1474698 | 1 | rs1320996 | chr6:56100431 | COL21A1 | chr6:55921389-56258892:- | 0.68 | 21.44 | 4.49E-85 | Pulse pressure |
| BRCA | cis | rs13191362 | 1 | rs13210412 | chr6:163019478 | PACRG | chr6:163148164-163736523:+ | 0.22 | 4.33 | 1.62E-5 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13210756 | chr6:163009030 | PACRG | chr6:163148164-163736523:+ | 0.2 | 4.02 | 6.15E-5 | Body mass index |
| BRCA | cis | rs742132 | 1 | rs1321252 | chr6:25616232 | SCGN | chr6:25652429-25702006:+ | 0.19 | 5.19 | 2.55E-7 | Uric acid levels |
| BRCA | cis | rs13191362 | 1 | rs13212608 | chr6:163032128 | PACRG | chr6:163148164-163736523:+ | 0.25 | 4.59 | 5.01E-6 | Body mass index |
| BRCA | cis | rs28381552 | 1 | rs13213285 | chr6:88329942 | C6orf162 | chr6:88032306-88052043:+ | -0.24 | -3.54 | 0.000424 | Obesity-related traits |
| BRCA | cis | rs28381552 | 1 | rs13213285 | chr6:88329942 | ZNF292 | chr6:87862551-87973404:+ | -0.18 | -3.54 | 0.000415 | Obesity-related traits |
| BRCA | cis | rs13191362 | 1 | rs13213408 | chr6:162998049 | PACRG | chr6:163148164-163736523:+ | 0.24 | 4.58 | 5.31E-6 | Body mass index |
| BRCA | cis | rs465969 | 1 | rs13213522 | chr6:111705341 | KIAA1919 | chr6:111580482-111590259:+ | 0.32 | 4.52 | 6.96E-6 | Psoriasis |
| BRCA | cis | rs339331 | 1 | rs1321366 | chr6:117240593 | FAM162B | chr6:117073360-117086886:- | -0.09 | -3.46 | 0.000554 | Prostate cancer |
| BRCA | cis | rs339331 | 1 | rs1321371 | chr6:117235656 | FAM162B | chr6:117073360-117086886:- | -0.1 | -3.48 | 0.000525 | Prostate cancer |
| BRCA | cis | rs339331 | 1 | rs1321372 | chr6:117237524 | FAM162B | chr6:117073360-117086886:- | -0.09 | -3.45 | 0.000577 | Prostate cancer |